NKB1 Mouse anti-Human, Unlabeled, Clone: DX9, BD

Description

Reacts with the killer cell inhibitory receptor (KIR), NKB1, a 70kDa glycoprotein, member of the Ig superfamily, expressed on a subset of natural killer cells and a small subset of T cells. Expression of NKB1 has been observed to vary among individuals. KIR molecules specifically recognize a certain group of HLA class I antigens. Interaction of NKB1 with specific HLA-B antigen on a target cell inhibits cell mediated cytotxicity, possibly by delivering a negative signal preventing lymphocyte activation. It is suggested that this MHC class I-KIR interaction works as a regulatory mechanism of NK and T-cell responses to antigenic challenge. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: DX6
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry