High-Performance Liquid Chromatograph_CoSense

Description

The Co-Sense for BA LC system represents an on-line sample preparation system, which utilizes restricted access media and the potential of a dilution channel for improving recovery from biological fluids. By using this unique on-line trapping system, the Co-Sense for BA can be used to directly inject and analyze a large volume of biological samples while achieving excellent sensitivity. Co-Sense for Impurities uses a concentration column or trap between the first and second dimension separations to increase sensitivity and ensure components are separated. These systems are used to automate sample pretreatment, increase sensitivity, and achieve high separation for complex matrices, mainly in the pharmaceutical/biopharmaceutical, food, and life science research markets

The Co-Sense for BA automatically and seamlessly performs all processes from sample pretreatment to analysis. This is achieved using a column-switching HPLC system equipped with the innovative Shimadzu Shim-pack MAYI-ODS pretreatment column and a unique on-line dilution bypass channel design. 

Co-Sense for Impurities offers both two-dimensional high separation chromatograply along with high sensitivity. It is especially useful for high-sensitivity analysis of ultra trace components or for analyzing components in complex matrices. The system uses trap concentration and on-line dilution after the first dimension separation. That means a guard column for the first dimension separation or other general-purpose columns can be used as the trap column in two-dimensional reversed phase plus reversed phase separation. It can also be used for more complicated two-dimensional separation, such as normal phase plus reversed phase separation.